BONE MARROW TRANSPLANTATION (BMT) its types,indication,complication

BONE

MARROW

TRANSPLANTATION

 (BMT)

• 
                 

Involve elimination the patients B.M . Stem cells

TYPES :

1-HLA matching sibling.               }

2- HLA matching relative.            }  ALLOGENEIC

3-Unrelated matching volunteers.}

4- Identical  twins .----------------- ®   SYNEGENIC

5- self (from patient’s marrow-----®AUTOLOGUS

INDICATIONS :-

ALLOGENEIC :-

1- Severe aplastic anaemia .

2- AML (acute myeloid leukemia ).

3- ALL (acute lymphoplastic leukemia )

4- CML (chronic myeloid leukemia )

5- Other malignant disorders of the marrow e.g . Myelodysplasia

6- Benign inherited disorders (thalassemia major , immune deficiency disease , mucopolysacc. , red cell aplasia and sickle cell anaemia )

AUTOLOGOUS

1- Malignant lymphoma (HD & NHL )

2-Other solid tumours e.g. breast cancer .

3-Aleukaemic leukaemia (AL)

4- Myeloma

5- For gene therapy of genetic disease e.g. adenosine deaminase deficiency .

                        COMPLICATIONS

EARLY (<100 days )

* Infection

*Acute GVHD

*Haemarrhagic cystitis

*Interstitial pneumonia

*Veno occlusive disease

*Cardiac failure .

LATE (>100 day)

-Infection

-ch. GVHD

-malabsorption

-chr .pulm. Disease

-catarct

Infertility

-Second malignancies