• HENOCH-SCHÖNLEIN PURPURA “anaphylactoid purpura” its causes and newest treatment

•          HENOCH-SCHÖNLEIN PURPURA

Also called “anaphylactoid purpura”

•          HSP is a systemic vasculitic syndrome with:

–        Palpable purpura

–        Arthralgias or arthritis

–        GIT involvement

–        Glomerulonephritis

•         
90% of cases reported in children

–        Peak in children aged 4-7

•          Male:Female (1.5:1)

•          50% follow a URI

•          Renal disease is more severe in adults

•          Tetrad of symptoms
–        Abdominal pain

–        Renal disease

–        Palpable purpura

–        Arthritis/arthralgias – more common in adults and most common in knees and ankles.  Generally self-limiting

•          MANAGEMENTUsually self-limiting (1-6 weeks)

•          Steroids:

–        may decrease tissue edema, may aid in arthralgias and some abdominal pain

–        Has not been shown to be beneficial in kidney disease or dermal manifestations

–        Does not lessen chance of recurrence

–        Does not shorten duration of disease