Alcoholic Cirrhosis its causes and newest line of treatment

Aetiology:

Alcoholic cirrhosis usually develops after more than 10 years of

heavy drinking……………. How ?

1- Alcohal à ↓↓appetite & malopserption à nutritional cirrhosis.

2-

Direct Hepatotoxic

H Acetaldhyde

dehydrogenase

Alcohol Alcohol

¯

+ +

Pathology: - Path. Of cirrhosis itself (def.)

- Micronodular cirrhosis.

- Mallory bodies: Oesinophilic deposits.
Clinical picture:

1- C/P of cirrhosis itself. (LCF > pH)

2- C/P of i cause (Alchoholism)

3- History of prolonged alcohol intake > 10 y`

4- Acute alcoholic hepatitis à enlarged tender liver.

à vomiting

5- Other features of ch. alchohlism:

à GIT: Gastritis, hepatitis, pancreatitis, malabsorptions.

à CNS: Korsakow's syndromes: tremore, Amenesia.

à blood: haemolytic anaemia.

à Immune: recurrent infection.

à Metabolic: Hypoglycaemia, hyperlipidaemia.

à Bilateral parotid enlargement.

Investigation: general inv. For cirrhosis.

Treatment:

· Stop alcohol intake.

· General measures for cirrhosis.

· Essential aa - cholchiaia – cortisone
see the pictures