Weight loss may be 'physiological' due to
dieting, exercise, starvation, or the decreased nutritional intake which
accompanies old age. Alternatively, weight loss may signify disease; a loss of
more than 3 kg over 6 months is significant. Hospital and general practice
weight records may be valuable,as
may reweighing patients at intervals, as sometimes weight is regained or
stabilizes in those with no obvious cause.
Pathological weight loss can be due to psychiatric illness, systemic disease, gastrointestinal causes or advanced disease of any specific organ system
Pathological weight loss can be due to psychiatric illness, systemic disease, gastrointestinal causes or advanced disease of any specific organ system
History
and examination
When weight loss is
due to serious organic disease a careful history, physical examination and
simple laboratory tests will usually define other features that lead to a
specific diagnosis
'Physiological' weight loss
'Physiological' weight loss
This may be obvious
in cases of young individuals who describe changes in physical activity or
social circumstances. It may be more difficult to be sure in older patients
when a history of nutritional intake may be unreliable; professional help from
a dietitian is often valuable.
Psychiatric
illness
Features of anorexia
nervosa, bulimia and affective disorders may only be apparent after formal
psychiatric input.
Alcoholic patients
lose weight as a consequence of self-neglect and poor dietary intake.
Systemic
diseases
Chronic infections
including tuberculosis, recurrent urinary or chest infections, and a range of
parasitic and protozoan infections should be considered. A history of foreign
travel, high-risk activities and specific features such as fever, night sweats,
rigors, productive cough and dysuria must be sought.
Sensitive, appropriate questions regarding lifestyle (promiscuous sexual
activity and drug misuse) may suggest HIV-related illness
Weight loss is a late
feature of disseminated malignancy (carcinoma, lymphoma or other hematological
disorders). Specific symptoms, physical signs, relevant imaging, or biochemical
or hematological abnormalities are almost invariable.
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