Gigantism and its clinical picture -Differential diagnosis of tall stature

Def. : ↑↑ GH secretion before fusion of epiphysis.

C/P :

1. Generalized overgrowth of skeleton & soft tissue.

2. Later on features of acromegaly develops.

3. Lastly decline stage usually occurs ( pituitary hypofunction.)

Differential diagnosis of tall stature

Causes :

1. Familial & racial : [ i commonest ]

2. Gigantism.

3. Excess androgen → tall children , short adult

4. Cerebral gigantism

5. Marfan’s syndrome.
see the pictures

6. Klinefelter syndrome (47 xxxy)