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Friday, January 31, 2014

Differential diagnosis of short stature and its causes

Causes :
1. : familial & constitutional : the commonest
2. Endocrinal
a. GH : Levi-lorian, Frolich’s, Laurance Moon Biedle.
b. T4 : cretinism & juvenile myxoedema.
c. sex hormones : precocious puberty.
d. cortisol : Cushing or excess steroid ttt.
3. Chronic sever illness during childhood :
a. CVS : sever rheumatic fever,
congenital heart diseases.
b. Lung : polycystic lung disease.
c. GIT : mal-absorption & malnutrition
d. Kidney : chronic nephritis.
4. Skeletal causes :
a. Congenital :
i. Aconrdoplasia : short limbs é normal trunk.
ii. Osteochondrodystrophy :
both limbs & trunk are short & deformed.
b. Acquired :
i. Rickets.
ii. Pott’s disease of spine.
iii. Paget’s disease of bone.
5. Genetic causes :
a. Mongolism [Down’s syndrome] trisomy 21.
b. Turner’s syndrome [ 45+ XO ].c. Noonan’s syndrome
see the pictures

short stature

short stature



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